TPDB

3D PDB MODEL

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TPDB ID TPDB66399

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FCLYELAR

FASTA

>TPDB66399|ACE inhibitors|length=8
FCLYELAR

Formula C47H71N11O12S1

Absent Amino Acids NDQGHIKMPSTWV

Common Amino Acids L

Mass 1014.21

PI 6.28

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -0

Boman Index -0.77

Hydrophobicity 0.675

Aliphatic Index 110.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 146.91

Polar Residues 2

number

1

A

1

R

0

N

0

D

1

C

1

E

0

Q

0

G

0

H

0

I

2

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

8

Formula

C47H71N11O12S1

Mass

1014.21

PI

6.28

Net Charge

-0

Boman Index

-0.77

Hydrophobicity

0.675

Chemical_Mass

1014.1964

Monoisotopic_Mass

1013.4988

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 31.63 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kaewsahnguan T., Noitang S., Sangtanoo P., Srimongkol P., Saisavoey T., Reamtong O., Choowongkomon K., Karnchanatat A.

Title

A novel angiotensin I-converting enzyme inhibitory peptide derived from the trypsin hydrolysates of salmon bone proteins. PLoS ONE, 16, e0256595, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C47H71N11O12S/c1-25(2)20-34(42(65)52-27(5)39(62)54-33(46(69)70)12-9-19-51-47(49)50)55-41(64)32(17-18-38(60)61)53-44(67)36(23-29-13-15-30(59)16-14-29)57-43(66)35(21-26(3)4)56-45(68)37(24-71)58-40(63)31(48)22-28-10-7-6-8-11-28/h6-8,10-11,13-16,25-27,31-37,59,71H,9,12,17-24,48H2,1-5H3,(H,52,65)(H,53,67)(H,54,62)(H,55,64)(H,56,68)(H,57,66)(H,58,63)(H,60,61)(H,69,70)(H4,49,50,51)/t27-,31-,32-,33-,34-,35-,36-,37-/m0/s1 InChIKey=VPZWDZGLXNQJAV-IFUGPJDHSA-N

Number_of_Residues

8