TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB66396

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

ETSGMKPTEL

FASTA

>TPDB66396|ACE inhibitors|length=10
ETSGMKPTEL

Formula C45H77N11O18S1

Absent Amino Acids ARNDCQHIFWYV

Common Amino Acids ET

Mass 1092.23

PI 4.26

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 2

Net Charge -1

Boman Index 5.11

Hydrophobicity -0.940

Aliphatic Index 39.00

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

2

E

0

Q

1

G

0

H

0

I

1

L

1

K

1

M

0

F

1

P

1

S

2

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 1 S: 1 T: 2 W: 0 Y: 0 V: 0

Length

10

Formula

C45H77N11O18S1

Mass

1092.23

PI

4.26

Net Charge

-1

Boman Index

5.11

Hydrophobicity

-0.940

Chemical_Mass

1092.2188

Monoisotopic_Mass

1091.5150

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 2.15 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Nuchprapha A. Paisansak S., Sangtanoo P., Srimongkol P., Saisavoey T., Reamtong O., Choowongkomond K., Karnchanatat A.

Title

Two novel ACE inhibitory peptides isolated from longan seeds: purification, inhibitory kinetics and mechanisms. RSC Adv., 10, 12711-12720, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)O InChI=1S/C45H77N11O18S/c1-22(2)19-29(45(73)74)52-39(67)26(12-14-34(63)64)50-42(70)36(24(4)59)55-41(69)31-10-8-17-56(31)44(72)28(9-6-7-16-46)51-40(68)27(15-18-75-5)49-32(60)20-48-38(66)30(21-57)53-43(71)35(23(3)58)54-37(65)25(47)11-13-33(61)62/h22-31,35-36,57-59H,6-21,46-47H2,1-5H3,(H,48,66)(H,49,60)(H,50,70)(H,51,68)(H,52,67)(H,53,71)(H,54,65)(H,55,69)(H,61,62)(H,63,64)(H,73,74)/t23-,24-,25+,26+,27+,28+,29+,30+,31+,35+,36+/m1/s1 InChIKey=AXEAQAKRNAOWET-VLTGQLKZSA-N

Number_of_Residues

10