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Peptide record

TPDB66381

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66381
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
EKGP
Physicochemical Analysis
C18H31N5O7
ARNDCQHILMFSTWYV
EGKP
429.47
6.94
1
1
0
-0
3.47
-2.350
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C18H31N5O7
429.47
6.94
-0
3.47
-2.350
429.4668
429.2216
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
129.90 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
O’Keeffe M. B., Norris R., Alashi M. A., Aluko R. E., FitzGerald R. J.
Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity. J. Funct. Foods, 34, 77–88, 2017
2017
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H31N5O7/c19-8-2-1-4-12(22-16(27)11(20)6-7-15(25)26)17(28)21-10-14(24)23-9-3-5-13(23)18(29)30/h11-13H,1-10,19-20H2,(H,21,28)(H,22,27)(H,25,26)(H,29,30)/t11-,12-,13-/m0/s1 InChIKey: MBMMOVYCGBEFHG-AVGNSLFASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4