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Peptide record

TPDB66366

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66366
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
DIGP
Physicochemical Analysis
C17H28N4O7
ARNCEQHLKMFSTWYV
DGIP
400.43
3.10
0
1
1
-1
1.38
-0.250
97.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C17H28N4O7
400.43
3.10
-1
1.38
-0.250
400.4257
400.1951
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
194.20 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
O’Keeffe M. B., Norris R., Alashi M. A., Aluko R. E., FitzGerald R. J.
Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity. J. Funct. Foods, 34, 77–88, 2017
2017
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1[C@H](C(=O)O)CCC1)[C@H](CC)C)CC(=O)O InChI=1S/C17H28N4O7/c1-3-9(2)14(20-15(25)10(18)7-13(23)24)16(26)19-8-12(22)21-6-4-5-11(21)17(27)28/h9-11,14H,3-8,18H2,1-2H3,(H,19,26)(H,20,25)(H,23,24)(H,27,28)/t9-,10-,11-,14-/m0/s1 InChIKey: LZUVKBYHTDPMEF-RMIALFOJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4