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Peptide record

TPDB66364

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66364
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
DFY
Physicochemical Analysis
C22H25N3O7
ARNCEQGHILKMPSTWV
DFY
443.46
3.10
0
1
2
-1
-0.84
-0.667
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1490
336.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C22H25N3O7
443.46
3.10
-1
-0.84
-0.667
443.4488
443.1686
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
44.35 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lafarga T., O’Connor P., Hayes M.
Identification of novel dipeptidyl peptidase-IV and angiotensin-I-converting enzyme inhibitory peptides from meat proteins using in silico analysis. Peptides, 59, 53-62, 2014
2014
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C22H25N3O7/c23-16(12-19(27)28)20(29)24-17(10-13-4-2-1-3-5-13)21(30)25-18(22(31)32)11-14-6-8-15(26)9-7-14/h1-9,16-18,26H,10-12,23H2,(H,24,29)(H,25,30)(H,27,28)(H,31,32)/t16-,17-,18-/m0/s1 InChIKey: NONWUQAWAANERO-BZSNNMDCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3