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Peptide record

TPDB66362

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66362
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
DAGP
Physicochemical Analysis
C14H22N4O7
RNCEQHILKMFSTWYV
ADGP
358.35
3.10
0
1
1
-1
1.52
-0.925
25.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C14H22N4O7
358.35
3.10
-1
1.52
-0.925
358.3462
358.1483
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
162.30 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
O’Keeffe M. B., Norris R., Alashi M. A., Aluko R. E., FitzGerald R. J.
Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity. J. Funct. Foods, 34, 77–88, 2017
2017
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C14H22N4O7/c1-7(17-13(23)8(15)5-11(20)21)12(22)16-6-10(19)18-4-2-3-9(18)14(24)25/h7-9H,2-6,15H2,1H3,(H,16,22)(H,17,23)(H,20,21)(H,24,25)/t7-,8-,9-/m0/s1 InChIKey: JAMWREFJQPXOKC-CIUDSAMLSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4