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Peptide record

TPDB66350

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66350
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
APPH
Physicochemical Analysis
C19H28N6O5
RNDCEQGILKMFSTWYV
P
420.47
7.85
1
0
1
+0
1.69
-1.150
25.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C19H28N6O5
420.47
7.85
+0
1.69
-1.150
420.4617
420.2115
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
31.91 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lafarga T., O’Connor P., Hayes M.
Identification of novel dipeptidyl peptidase-IV and angiotensin-I-converting enzyme inhibitory peptides from meat proteins using in silico analysis. Peptides, 59, 53-62, 2014
2014
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)O InChI=1S/C19H28N6O5/c1-11(20)17(27)25-7-3-5-15(25)18(28)24-6-2-4-14(24)16(26)23-13(19(29)30)8-12-9-21-10-22-12/h9-11,13-15H,2-8,20H2,1H3,(H,21,22)(H,23,26)(H,29,30)/t11-,13-,14-,15-/m0/s1 InChIKey: QYFCXVGQFXOWPP-MXAVVETBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
4