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Peptide record

TPDB66339

ACE inhibitor from dry-cured ham Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Anti-inflammatory iDPPIV standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66339
ACE inhibitor from dry-cured ham Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Anti-inflammatory iDPPIV
Cardiometabolic peptides Immunity and inflammation peptides
Peptipedia iDPPIV
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
AAATP
Physicochemical Analysis
C18H31N5O7
RNDCEQGHILKMFSWYV
A
429.47
6.02
0
0
3
-0
0.08
0.620
60.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C18H31N5O7
429.47
6.02
-0
0.08
0.620
429.4668
429.2216
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
100.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Escudero E., Mora L., Fraser P.D., Aristoy M.-C., Arihara K., Toldra F.
Purification and identification of antihypertensive peptides in Spanish dry-cured ham. Journal of Proteomics, 78, 499–507, 2013
2013
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H31N5O7/c1-8(19)14(25)20-9(2)15(26)21-10(3)16(27)22-13(11(4)24)17(28)23-7-5-6-12(23)18(29)30/h8-13,24H,5-7,19H2,1-4H3,(H,20,25)(H,21,26)(H,22,27)(H,29,30)/t8-,9-,10-,11+,12-,13-/m0/s1 InChIKey=HMHKGUIEVXGLOK-PJGZEUCASA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8639) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9959)
Evidence 2 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Anti-inflammatory
anti inflammatory
ai

Source & Reference

NA
Martínez-Sánchez S. M., Pérez-Sánchez H., Gabaldón J. A., Abellán-Alemán J., Montoro-García S.
Multifunctional peptides from Spanish dry-cured pork ham: endothelial responses and molecular modeling studies. Int. J. Mol. Sci., 20, 4204, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H31N5O7/c1-8(19)14(25)20-9(2)15(26)21-10(3)16(27)22-13(11(4)24)17(28)23-7-5-6-12(23)18(29)30/h8-13,24H,5-7,19H2,1-4H3,(H,20,25)(H,21,26)(H,22,27)(H,29,30)/t8-,9-,10-,11+,12-,13-/m0/s1 InChIKey=HMHKGUIEVXGLOK-PJGZEUCASA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8546) the EROP-Moscow database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8639)
Evidence 3 Activity

Activity

IC50
iDPPIV
6470.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Gallego M., Aristoy M.-C., Toldrá F.
Dipeptidyl peptidase IV inhibitory peptides generated in Spanish dry-cured ham. Meat Science 96, 757-761, 2014
2014
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C18H31N5O7/c1-8(19)14(25)20-9(2)15(26)21-10(3)16(27)22-13(11(4)24)17(28)23-7-5-6-12(23)18(29)30/h8-13,24H,5-7,19H2,1-4H3,(H,20,25)(H,21,26)(H,22,27)(H,29,30)/t8-,9-,10-,11+,12-,13-/m0/s1 InChIKey=HMHKGUIEVXGLOK-PJGZEUCASA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 8546) the EROP-Moscow database Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9959)
Additional Detail Fields 1 fields
5