TPDB

3D PDB MODEL

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TPDB ID TPDB66335

Peptide_Name

angiogenin fragment:108-123

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

ENGLPVHLDQSIFRRP

FASTA

>TPDB66335|ACE inhibitors|length=16
ENGLPVHLDQSIFRRP

Formula C83H132N26O24

Absent Amino Acids ACKMTWY

Common Amino Acids RLP

Mass 1878.12

PI 7.85

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 5

Net Charge +0

Boman Index 5.38

Hydrophobicity -0.719

Aliphatic Index 91.25

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

2

R

1

N

1

D

0

C

1

E

1

Q

1

G

1

H

1

I

2

L

0

K

0

M

1

F

2

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 1 L: 2 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

16

Formula

C83H132N26O24

Mass

1878.12

PI

7.85

Net Charge

+0

Boman Index

5.38

Hydrophobicity

-0.719

Chemical_Mass

1878.0907

Monoisotopic_Mass

1876.9878

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Rybak S. M., Auld D. S., St Clair D. K., Yao Q.-Z., Fett J. W.

Title

C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin. Biochem. Biophys. Res. Commun., 162, 535-543

Year 1989

Literature Source Journal

Other

Number of Residues 16

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C83H132N26O24/c1-9-44(8)66(78(129)103-52(33-45-17-11-10-12-18-45)72(123)97-48(19-13-27-92-82(87)88)69(120)99-50(20-14-28-93-83(89)90)79(130)109-30-16-22-59(109)81(132)133)107-75(126)57(39-110)105-70(121)49(24-25-60(85)111)98-74(125)55(36-64(116)117)102-71(122)51(31-41(2)3)101-73(124)53(34-46-37-91-40-95-46)104-77(128)65(43(6)7)106-76(127)58-21-15-29-108(58)80(131)56(32-42(4)5)96-62(113)38-94-68(119)54(35-61(86)112)100-67(118)47(84)23-26-63(114)115/h10-12,17-18,37,40-44,47-59,65-66,110H,9,13-16,19-36,38-39,84H2,1-8H3,(H2,85,111)(H2,86,112)(H,91,95)(H,94,119)(H,96,113)(H,97,123)(H,98,125)(H,99,120)(H,100,118)(H,101,124)(H,102,122)(H,103,129)(H,104,128)(H,105,121)(H,106,127)(H,107,126)(H,114,115)(H,116,117)(H,132,133)(H4,87,88,92)(H4,89,90,93)/t44-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,65-,66-/m0/s1 InChIKey=SLPUTWRGWJPLQC-OHUKJTBKSA-N

Number_of_Residues

16