TPDB

3D PDB MODEL

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TPDB ID TPDB66331

Peptide_Name

angiogenin fragment:108-122

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 15-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

ENGLPVHLDQSIFRR

FASTA

>TPDB66331|ACE inhibitors|length=15
ENGLPVHLDQSIFRR

Formula C78H125N25O23

Absent Amino Acids ACKMTWY

Common Amino Acids RL

Mass 1781.00

PI 7.85

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 5

Net Charge +0

Boman Index 4.93

Hydrophobicity -0.660

Aliphatic Index 97.33

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

2

R

1

N

1

D

0

C

1

E

1

Q

1

G

1

H

1

I

2

L

0

K

0

M

1

F

1

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 1 L: 2 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

15

Formula

C78H125N25O23

Mass

1781.00

PI

7.85

Net Charge

+0

Boman Index

4.93

Hydrophobicity

-0.660

Chemical_Mass

1780.9758

Monoisotopic_Mass

1779.9352

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Rybak S. M., Auld D. S., St Clair D. K., Yao Q.-Z., Fett J. W.

Title

C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin. Biochem. Biophys. Res. Commun., 162, 535-543

Year 1989

Literature Source Journal

Other

Number of Residues 15

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@@]([H])(C)CC InChI=1S/C78H125N25O23/c1-9-41(8)62(74(123)98-49(30-42-16-11-10-12-17-42)68(117)92-45(18-13-25-87-77(82)83)65(114)94-47(76(125)126)19-14-26-88-78(84)85)102-71(120)54(36-104)100-66(115)46(22-23-56(80)105)93-70(119)52(33-60(110)111)97-67(116)48(28-38(2)3)96-69(118)50(31-43-34-86-37-90-43)99-73(122)61(40(6)7)101-72(121)55-20-15-27-103(55)75(124)53(29-39(4)5)91-58(107)35-89-64(113)51(32-57(81)106)95-63(112)44(79)21-24-59(108)109/h10-12,16-17,34,37-41,44-55,61-62,104H,9,13-15,18-33,35-36,79H2,1-8H3,(H2,80,105)(H2,81,106)(H,86,90)(H,89,113)(H,91,107)(H,92,117)(H,93,119)(H,94,114)(H,95,112)(H,96,118)(H,97,116)(H,98,123)(H,99,122)(H,100,115)(H,101,121)(H,102,120)(H,108,109)(H,110,111)(H,125,126)(H4,82,83,87)(H4,84,85,88)/t41-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,61-,62-/m0/s1 InChIKey=OQNNLMANCATHNH-GMBIJEMUSA-N

Number_of_Residues

15