TPDB

3D PDB MODEL

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TPDB ID TPDB66330

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

GLTGRPGDAGPQGK

FASTA

>TPDB66330|ACE inhibitors|length=14
GLTGRPGDAGPQGK

Formula C54H91N19O19

Absent Amino Acids NCEHIMFSWYV

Common Amino Acids G

Mass 1310.43

PI 10.09

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 2

Net Charge +1

Boman Index 3.97

Hydrophobicity -1.121

Aliphatic Index 35.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

1

R

0

N

1

D

0

C

0

E

1

Q

5

G

0

H

0

I

1

L

1

K

0

M

0

F

2

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 5 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

14

Formula

C54H91N19O19

Mass

1310.43

PI

10.09

Net Charge

+1

Boman Index

3.97

Hydrophobicity

-1.121

Chemical_Mass

1310.4126

Monoisotopic_Mass

1309.6718

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 453.40 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Dara P. K., Elavarasan K., Shamasundar B. A.

Title

Improved utilization of croaker skin waste and freshwater carps visceral waste: conversion of waste to health benefitting peptides. Int. J. Pept. Res. Therapeut., 26, 2641–2651, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 14

Additional Info

BIOPEP-UWM database of bioactive peptides: SMILES: NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C54H91N19O19/c1-27(2)20-33(68-38(76)22-56)48(86)71-44(29(4)74)51(89)63-25-39(77)66-31(11-7-17-60-54(58)59)52(90)73-19-9-12-35(73)49(87)62-24-41(79)69-34(21-43(81)82)47(85)65-28(3)45(83)64-26-42(80)72-18-8-13-36(72)50(88)70-30(14-15-37(57)75)46(84)61-23-40(78)67-32(53(91)92)10-5-6-16-55/h27-36,44,74H,5-26,55-56H2,1-4H3,(H2,57,75)(H,61,84)(H,62,87)(H,63,89)(H,64,83)(H,65,85)(H,66,77)(H,67,78)(H,68,76)(H,69,79)(H,70,88)(H,71,86)(H,81,82)(H,91,92)(H4,58,59,60)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,44-/m0/s1 InChIKey=WOGFNNBWGKVKJC-ZBPKIDBDSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Number_of_Residues

14