TPDB

3D PDB MODEL

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TPDB ID TPDB66329

Peptide_Name

ACE inhibitor from pea

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

KEDDEEEEQGEEE

FASTA

>TPDB66329|ACE inhibitors|length=13
KEDDEEEEQGEEE

Formula C61H91N15O35

Absent Amino Acids ARNCHILMFPSTWYV

Common Amino Acids E

Mass 1594.47

PI 3.25

Basic Residues 1

Acidic Residues 10

Hydrophobic Residues 0

Net Charge -9

Boman Index 20.20

Hydrophobicity -3.292

Aliphatic Index 0.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

2

D

0

C

8

E

1

Q

1

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 0 E: 8 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

13

Formula

C61H91N15O35

Mass

1594.47

PI

3.25

Net Charge

-9

Boman Index

20.20

Hydrophobicity

-3.292

Chemical_Mass

1594.4511

Monoisotopic_Mass

1593.5778

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 64.04 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Jakubczyk A., Karaś M., Baraniak B., Pietrzak M.

Title

The impact of fermentation and in vitro digestion on formation angiotensin converting enzyme (ACE) inhibitory peptides from pea proteins. Food Chem. 141, 3774–3780, 2013

Year 2013

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C61H91N15O35/c62-22-2-1-3-26(63)50(99)67-29(6-15-41(81)82)58(107)75-37(24-49(97)98)60(109)76-36(23-48(95)96)59(108)73-33(10-19-45(89)90)56(105)72-32(9-18-44(87)88)55(104)71-31(8-17-43(85)86)54(103)70-30(7-16-42(83)84)53(102)68-27(4-13-38(64)77)51(100)65-25-39(78)66-28(5-14-40(79)80)52(101)69-34(11-20-46(91)92)57(106)74-35(61(110)111)12-21-47(93)94/h26-37H,1-25,62-63H2,(H2,64,77)(H,65,100)(H,66,78)(H,67,99)(H,68,102)(H,69,101)(H,70,103)(H,71,104)(H,72,105)(H,73,108)(H,74,106)(H,75,107)(H,76,109)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H,97,98)(H,110,111)/t26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-/m0/s1 InChIKey=OIDSNAQTAVCKRF-HIGYSMTCSA-N

Number_of_Residues

13