TPDB

3D PDB MODEL

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TPDB ID TPDB66322

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

EIVPNSAEERLH

FASTA

>TPDB66322|ACE inhibitors|length=12
EIVPNSAEERLH

Formula C59H96N18O21

Absent Amino Acids DCQGKMFTWY

Common Amino Acids E

Mass 1393.52

PI 4.53

Basic Residues 2

Acidic Residues 3

Hydrophobic Residues 4

Net Charge -2

Boman Index 7.86

Hydrophobicity -0.817

Aliphatic Index 97.50

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

1

R

1

N

0

D

0

C

3

E

0

Q

0

G

1

H

1

I

1

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 0 C: 0 E: 3 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

12

Formula

C59H96N18O21

Mass

1393.52

PI

4.53

Net Charge

-2

Boman Index

7.86

Hydrophobicity

-0.817

Chemical_Mass

1393.4977

Monoisotopic_Mass

1392.6975

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Villegas J. M., Picariello G., Mamone G., Espeche Turbay M. B., Savoy de Giori G., Hebert E. M.

Title

Milk-derived angiotensin-I-converting enzyme-inhibitory peptides generated by Lactobacillus delbrueckii subsp. lactis CRL 581. Peptidomics 1: 22–29, 2014.

Year 2014

Literature Source Journal

Other

Number of Residues 12

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCC(O)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC1=CN=CN1)C(O)=O InChI=1S/C59H96N18O21/c1-8-29(6)46(76-48(87)32(60)13-16-42(80)81)56(95)75-45(28(4)5)57(96)77-20-10-12-40(77)55(94)72-37(23-41(61)79)53(92)74-39(25-78)54(93)67-30(7)47(86)68-34(14-17-43(82)83)50(89)70-35(15-18-44(84)85)51(90)69-33(11-9-19-65-59(62)63)49(88)71-36(21-27(2)3)52(91)73-38(58(97)98)22-31-24-64-26-66-31/h24,26-30,32-40,45-46,78H,8-23,25,60H2,1-7H3,(H2,61,79)(H,64,66)(H,67,93)(H,68,86)(H,69,90)(H,70,89)(H,71,88)(H,72,94)(H,73,91)(H,74,92)(H,75,95)(H,76,87)(H,80,81)(H,82,83)(H,84,85)(H,97,98)(H4,62,63,65)/t29-,30-,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1 InChIKey: BCYZAWVRWXUBRJ-AKZWAMMKSA-N

Number_of_Residues

12