TPDB

3D PDB MODEL

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TPDB ID TPDB66320

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

IVRDPNGMGAW

FASTA

>TPDB66320|ACE inhibitors|length=11
IVRDPNGMGAW

Formula C53H82N16O15S1

Absent Amino Acids CEQHLKFSTY

Common Amino Acids G

Mass 1215.39

PI 6.78

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -0

Boman Index 0.44

Hydrophobicity -0.218

Aliphatic Index 70.91

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 452.53

Polar Residues 1

number

1

A

1

R

1

N

1

D

0

C

0

E

0

Q

2

G

0

H

1

I

0

L

0

K

1

M

0

F

1

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

11

Formula

C53H82N16O15S1

Mass

1215.39

PI

6.78

Net Charge

-0

Boman Index

0.44

Hydrophobicity

-0.218

Chemical_Mass

1215.3792

Monoisotopic_Mass

1214.5848

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Rawendra R. D. S., Aisha, Chang C., Aulanni'am, Chen H.-H., Huang T.-C., Hsu J.-L.

Title

A novel angiotensin converting enzyme inhibitory peptide derived from proteolytic digest of Chinese soft-shelled turtle egg white proteins. J. Proteomics, 94, 359-369, 2013

Year 2013

Literature Source Journal

Other

Number of Residues 11

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(NC(=O)CNC(=O)[C@]([H])(CCSC)NC(=O)CNC(=O)[C@]([H])(CC(N)=O)NC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)[C@@H](C)CC)C(C)C)C(=O)N[C@@]([H])(CC1=CNC2=C1C=CC=C2)C(O)=O InChI=1S/C53H82N16O15S/c1-7-27(4)42(55)49(80)68-43(26(2)3)50(81)64-32(14-10-17-58-53(56)57)47(78)66-35(22-41(73)74)51(82)69-18-11-15-37(69)48(79)65-34(21-38(54)70)46(77)61-25-40(72)63-33(16-19-85-6)45(76)60-24-39(71)62-28(5)44(75)67-36(52(83)84)20-29-23-59-31-13-9-8-12-30(29)31/h8-9,12-13,23,26-28,32-37,42-43,59H,7,10-11,14-22,24-25,55H2,1-6H3,(H2,54,70)(H,60,76)(H,61,77)(H,62,71)(H,63,72)(H,64,81)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,73,74)(H,83,84)(H4,56,57,58)/t27-,28-,32-,33-,34-,35-,36-,37-,42-,43-/m0/s1 InChIKey: FZWSQNJZFFHMOR-NZTOELLASA-N

Number_of_Residues

11