TPDB

3D PDB MODEL

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TPDB ID TPDB66319

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

FDKLPGFGD

FASTA

>TPDB66319|ACE inhibitors|length=9
FDKLPGFGD

Formula C47H66N10O14

Absent Amino Acids ARNCEQHIMSTWYV

Common Amino Acids DGF

Mass 995.10

PI 3.88

Basic Residues 1

Acidic Residues 2

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.10

Hydrophobicity -0.433

Aliphatic Index 43.33

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

2

D

0

C

0

E

0

Q

2

G

0

H

0

I

1

L

1

K

0

M

2

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C47H66N10O14

Mass

995.10

PI

3.88

Net Charge

-1

Boman Index

1.10

Hydrophobicity

-0.433

Chemical_Mass

995.0829

Monoisotopic_Mass

994.4744

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Fan H., Wang J., Liao W., Jiang J., Wu J.

Title

Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N2[C@@H](CCC2)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O InChI=1S/C47H66N10O14/c1-27(2)20-34(56-43(66)31(16-9-10-18-48)54-44(67)33(23-39(60)61)55-41(64)30(49)21-28-12-5-3-6-13-28)46(69)57-19-11-17-36(57)45(68)51-26-37(58)52-32(22-29-14-7-4-8-15-29)42(65)50-25-38(59)53-35(47(70)71)24-40(62)63/h3-8,12-15,27,30-36H,9-11,16-26,48-49H2,1-2H3,(H,50,65)(H,51,68)(H,52,58)(H,53,59)(H,54,67)(H,55,64)(H,56,66)(H,60,61)(H,62,63)(H,70,71)/t30-,31-,32-,33-,34-,35-,36-/m0/s1 InChIKey=BNQFGXCYPVRJFA-QJCLFNHPSA-N

Number_of_Residues

9