TPDB

3D PDB MODEL

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TPDB ID TPDB66317

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

SFHPYFSY

FASTA

>TPDB66317|ACE inhibitors|length=8
SFHPYFSY

Formula C53H62N10O13

Absent Amino Acids ARNDCEQGILKMTWV

Common Amino Acids FSY

Mass 1047.13

PI 7.71

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -2.47

Hydrophobicity -0.425

Aliphatic Index 0.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 284.59

Polar Residues 4

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

2

F

1

P

2

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 2 V: 0

Length

8

Formula

C53H62N10O13

Mass

1047.13

PI

7.71

Net Charge

+0

Boman Index

-2.47

Hydrophobicity

-0.425

Chemical_Mass

1047.1161

Monoisotopic_Mass

1046.4483

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 82.71 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.

Title

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525

Year 2015

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [C@H](N)(CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC6=CC=C(C=C6)O)C(O)=O InChI=1S/C53H62N10O13/c54-38(28-64)46(68)57-39(22-31-8-3-1-4-9-31)48(70)60-42(26-35-27-55-30-56-35)52(74)63-21-7-12-45(63)51(73)59-41(24-33-13-17-36(66)18-14-33)47(69)58-40(23-32-10-5-2-6-11-32)49(71)62-44(29-65)50(72)61-43(53(75)76)25-34-15-19-37(67)20-16-34/h1-6,8-11,13-20,27,30,38-45,64-67H,7,12,21-26,28-29,54H2,(H,55,56)(H,57,68)(H,58,69)(H,59,73)(H,60,70)(H,61,72)(H,62,71)(H,75,76)/t38-,39-,40-,41-,42-,43-,44-,45-/m0/s1 InChIKey: MKNMHSVYIOXONG-FKRLEHQTSA-N

Number_of_Residues

8