TPDB

3D PDB MODEL

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TPDB ID TPDB66316

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

SDNRNQGY

FASTA

>TPDB66316|ACE inhibitors|length=8
SDNRNQGY

Formula C37H56N14O16

Absent Amino Acids ACEHILKMFPTWV

Common Amino Acids N

Mass 952.94

PI 6.71

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 2.66

Hydrophobicity -2.625

Aliphatic Index 0.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 156.36

Polar Residues 5

number

0

A

1

R

2

N

1

D

0

C

0

E

1

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

8

Formula

C37H56N14O16

Mass

952.94

PI

6.71

Net Charge

-0

Boman Index

2.66

Hydrophobicity

-2.625

Chemical_Mass

952.9225

Monoisotopic_Mass

952.3986

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Yousr M., Howell N.

Title

Antioxidant and ACE inhibitory bioactive peptides purified from egg yolk proteins. Int. J. Mol. Sci., 16, 29161–29178, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C37H56N14O16/c38-18(15-52)30(60)49-23(13-29(58)59)35(65)51-22(12-27(41)56)33(63)47-19(2-1-9-44-37(42)43)32(62)50-21(11-26(40)55)34(64)48-20(7-8-25(39)54)31(61)45-14-28(57)46-24(36(66)67)10-16-3-5-17(53)6-4-16/h3-6,18-24,52-53H,1-2,7-15,38H2,(H2,39,54)(H2,40,55)(H2,41,56)(H,45,61)(H,46,57)(H,47,63)(H,48,64)(H,49,60)(H,50,62)(H,51,65)(H,58,59)(H,66,67)(H4,42,43,44)/t18-,19-,20-,21-,22-,23-,24-/m0/s1 InChIKey: BRYBOERJYJAGEE-LQDRYOBXSA-N

Number_of_Residues

8