TPDB

3D PDB MODEL

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TPDB ID TPDB66312

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

PFPEVFGK

FASTA

>TPDB66312|ACE inhibitors|length=8
PFPEVFGK

Formula C46H65N9O11

Absent Amino Acids ARNDCQHILMSTWY

Common Amino Acids FP

Mass 920.08

PI 6.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -0

Boman Index 1.73

Hydrophobicity -0.150

Aliphatic Index 36.25

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

1

G

0

H

0

I

0

L

1

K

0

M

2

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

8

Formula

C46H65N9O11

Mass

920.08

PI

6.94

Net Charge

-0

Boman Index

1.73

Hydrophobicity

-0.150

Chemical_Mass

920.0594

Monoisotopic_Mass

919.4788

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Paul M., Phillips J. G., Renye J. A.

Title

Short communication: Measuring the angiotensin-converting enzyme inhibitory activity of an 8-amino acid (8mer) fragment of the C12 antihypertensive peptide. J. Dairy Sci., 99, 3263-3266, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@H](CCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C46H65N9O11/c1-28(2)39(44(63)52-34(25-29-13-5-3-6-14-29)40(59)49-27-37(56)50-33(46(65)66)17-9-10-22-47)54-42(61)32(20-21-38(57)58)51-43(62)36-19-12-24-55(36)45(64)35(26-30-15-7-4-8-16-30)53-41(60)31-18-11-23-48-31/h3-8,13-16,28,31-36,39,48H,9-12,17-27,47H2,1-2H3,(H,49,59)(H,50,56)(H,51,62)(H,52,63)(H,53,60)(H,54,61)(H,57,58)(H,65,66)/t31-,32-,33-,34-,35-,36-,39-/m0/s1 InChIKey: QFLAEIMYURSZLS-RCMAVRGVSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

8