TPDB

3D PDB MODEL

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TPDB ID TPDB66309

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

EKVNELSK

FASTA

>TPDB66309|ACE inhibitors|length=8
EKVNELSK

Formula C40H71N11O15

Absent Amino Acids ARDCQGHIMFPTWY

Common Amino Acids EK

Mass 946.07

PI 7.06

Basic Residues 2

Acidic Residues 2

Hydrophobic Residues 2

Net Charge +0

Boman Index 6.08

Hydrophobicity -1.387

Aliphatic Index 85.00

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

2

E

0

Q

0

G

0

H

0

I

1

L

2

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

8

Formula

C40H71N11O15

Mass

946.07

PI

7.06

Net Charge

+0

Boman Index

6.08

Hydrophobicity

-1.387

Chemical_Mass

946.0536

Monoisotopic_Mass

945.5114

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 5998.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Tu M., Liu H., Zhang R., Chen H., Mao F., Cheng S., Lu W., Du M.

Title

Analysis and evaluation of the inhibitory mechanism of a novel angiotensin-I-converting enzyme inhibitory peptide derived from casein hydrolysate. J. Agric. Food Chem., 66, 4139-4144, 2018

Year 2018

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C40H71N11O15/c1-20(2)17-26(36(61)50-28(19-52)38(63)47-25(40(65)66)10-6-8-16-42)48-34(59)24(12-14-31(56)57)46-37(62)27(18-29(44)53)49-39(64)32(21(3)4)51-35(60)23(9-5-7-15-41)45-33(58)22(43)11-13-30(54)55/h20-28,32,52H,5-19,41-43H2,1-4H3,(H2,44,53)(H,45,58)(H,46,62)(H,47,63)(H,48,59)(H,49,64)(H,50,61)(H,51,60)(H,54,55)(H,56,57)(H,65,66)/t22-,23-,24-,25-,26-,27-,28-,32-/m0/s1 InChIKey: MOOTXKNVPZAJNW-KUDVIRNGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

8