TPDB

3D PDB MODEL

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TPDB ID TPDB66308

Peptide_Name

ACE inhibitor from alphas1-CN (143-150)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

AYFYPELF

FASTA

>TPDB66308|ACE inhibitors|length=8
AYFYPELF

Formula C55H68N8O13

Absent Amino Acids RNDCQGHIKMSTWV

Common Amino Acids FY

Mass 1049.19

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 6

Net Charge -1

Boman Index -2.40

Hydrophobicity 0.437

Aliphatic Index 61.25

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 284.03

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

2

F

1

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

8

Formula

C55H68N8O13

Mass

1049.19

PI

3.29

Net Charge

-1

Boman Index

-2.40

Hydrophobicity

0.437

Chemical_Mass

1049.1715

Monoisotopic_Mass

1048.4889

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors De Gobba C., Tompa G., Otte J.

Title

Bioactive peptides from caseins released by cold active proteolytic enzymes from Arsukibacterium ikkense. Food Chemistry 165, 205-215, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)O InChI=1S/C55H68N8O13/c1-32(2)27-41(50(70)62-45(55(75)76)31-35-13-8-5-9-14-35)59-49(69)40(24-25-47(66)67)57-53(73)46-15-10-26-63(46)54(74)44(30-37-18-22-39(65)23-19-37)61-52(72)43(28-34-11-6-4-7-12-34)60-51(71)42(58-48(68)33(3)56)29-36-16-20-38(64)21-17-36/h4-9,11-14,16-23,32-33,40-46,64-65H,10,15,24-31,56H2,1-3H3,(H,57,73)(H,58,68)(H,59,69)(H,60,71)(H,61,72)(H,62,70)(H,66,67)(H,75,76)/t33-,40-,41-,42-,43-,44-,45-,46-/m0/s1 InChIKey=HVTULYGXQZDWRE-VZMLCZHDSA-N

Number_of_Residues

8