TPDB

3D PDB MODEL

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TPDB ID TPDB66307

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

AFVGYVLP

FASTA

>TPDB66307|ACE inhibitors|length=8
AFVGYVLP

Formula C44H64N8O10

Absent Amino Acids RNDCEQHIKMSTW

Common Amino Acids V

Mass 865.04

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 6

Net Charge -0

Boman Index -2.20

Hydrophobicity 1.688

Aliphatic Index 133.75

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 172.25

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 2

Length

8

Formula

C44H64N8O10

Mass

865.04

PI

5.94

Net Charge

-0

Boman Index

-2.20

Hydrophobicity

1.688

Chemical_Mass

865.0240

Monoisotopic_Mass

864.4730

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 18.02 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.

Title

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525

Year 2015

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](C)(N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C(C)C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C44H64N8O10/c1-24(2)20-33(43(60)52-19-11-14-34(52)44(61)62)49-42(59)37(26(5)6)51-39(56)31(22-29-15-17-30(53)18-16-29)47-35(54)23-46-41(58)36(25(3)4)50-40(57)32(48-38(55)27(7)45)21-28-12-9-8-10-13-28/h8-10,12-13,15-18,24-27,31-34,36-37,53H,11,14,19-23,45H2,1-7H3,(H,46,58)(H,47,54)(H,48,55)(H,49,59)(H,50,57)(H,51,56)(H,61,62)/t27-,31-,32-,33-,34-,36-,37-/m0/s1 InChIKey: ZKQHDXXDEFFALG-FLKPBYFPSA-N

Number_of_Residues

8