TPDB

3D PDB MODEL

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TPDB ID TPDB66305

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

YVPHWNL

FASTA

>TPDB66305|ACE inhibitors|length=7
YVPHWNL

Formula C46H61N11O10

Absent Amino Acids ARDCEQGIKMFST

Common Amino Acids NHLPWYV

Mass 928.06

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -1.45

Hydrophobicity -0.357

Aliphatic Index 97.14

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 753.19

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 1

Length

7

Formula

C46H61N11O10

Mass

928.06

PI

7.77

Net Charge

+0

Boman Index

-1.45

Hydrophobicity

-0.357

Chemical_Mass

928.0418

Monoisotopic_Mass

927.4589

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.14 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Wang F. J., Yin X. Y., Regenstein J. M., Wang J. Z.

Title

Separation and purification of angiotensin I converting enzyme (ACE) inhibitory peptides from walnuts (Juglans regia L.) meal. Eur. Food Res. Technol., 242, 911-918, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)N[C@@H](CC4=C[N]([H])C5=CC=CC=C45)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C46H61N11O10/c1-24(2)16-36(46(66)67)55-43(63)35(20-38(48)59)53-41(61)33(18-27-21-50-32-9-6-5-8-30(27)32)52-42(62)34(19-28-22-49-23-51-28)54-44(64)37-10-7-15-57(37)45(65)39(25(3)4)56-40(60)31(47)17-26-11-13-29(58)14-12-26/h5-6,8-9,11-14,21-25,31,33-37,39,50,58H,7,10,15-20,47H2,1-4H3,(H2,48,59)(H,49,51)(H,52,62)(H,53,61)(H,54,64)(H,55,63)(H,56,60)(H,66,67)/t31-,33-,34-,35-,36-,37-,39-/m0/s1 InChIKey=MKSWPMZPZRGQNE-IDWCMAOESA-N

Number_of_Residues

7