TPDB

3D PDB MODEL

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TPDB ID TPDB66304

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

YVPHWDL

FASTA

>TPDB66304|ACE inhibitors|length=7
YVPHWDL

Formula C46H60N10O11

Absent Amino Acids ARNCEQGIKMFST

Common Amino Acids DHLPWYV

Mass 929.04

PI 4.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -1

Boman Index -0.64

Hydrophobicity -0.357

Aliphatic Index 97.14

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 752.39

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 1

Length

7

Formula

C46H60N10O11

Mass

929.04

PI

4.94

Net Charge

-1

Boman Index

-0.64

Hydrophobicity

-0.357

Chemical_Mass

929.0266

Monoisotopic_Mass

928.4429

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.17 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Wang F. J., Yin X. Y., Regenstein J. M., Wang J. Z.

Title

Separation and purification of angiotensin I converting enzyme (ACE) inhibitory peptides from walnuts (Juglans regia L.) meal. Eur. Food Res. Technol., 242, 911-918, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)N[C@@H](CC4=C[N]([H])C5=CC=CC=C45)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C46H60N10O11/c1-24(2)16-36(46(66)67)54-43(63)35(20-38(58)59)52-41(61)33(18-27-21-49-32-9-6-5-8-30(27)32)51-42(62)34(19-28-22-48-23-50-28)53-44(64)37-10-7-15-56(37)45(65)39(25(3)4)55-40(60)31(47)17-26-11-13-29(57)14-12-26/h5-6,8-9,11-14,21-25,31,33-37,39,49,57H,7,10,15-20,47H2,1-4H3,(H,48,50)(H,51,62)(H,52,61)(H,53,64)(H,54,63)(H,55,60)(H,58,59)(H,66,67)/t31-,33-,34-,35-,36-,37-,39-/m0/s1 InChIKey=LIHBXVQXVJECNB-IDWCMAOESA-N

Number_of_Residues

7