TPDB

3D PDB MODEL

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TPDB ID TPDB66298

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

RVFDGAV

FASTA

>TPDB66298|ACE inhibitors|length=7
RVFDGAV

Formula C34H54N10O10

Absent Amino Acids NCEQHILKMPSTWY

Common Amino Acids V

Mass 762.86

PI 6.78

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index 0.89

Hydrophobicity 0.657

Aliphatic Index 97.14

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

1

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C34H54N10O10

Mass

762.86

PI

6.78

Net Charge

-0

Boman Index

0.89

Hydrophobicity

0.657

Chemical_Mass

762.8514

Monoisotopic_Mass

762.4012

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1006.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ma F.-F., Wang H., Wei C.-K., Thakur K., Wei Z.-J., Jiang L.

Title

Three Novel ACE Inhibitory Peptides Isolated From Ginkgo biloba Seeds: Purification, Inhibitory Kinetic and Mechanism. Front. Pharmacol., 9, 1579, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C34H54N10O10/c1-17(2)26(43-29(49)21(35)12-9-13-38-34(36)37)32(52)42-22(14-20-10-7-6-8-11-20)31(51)41-23(15-25(46)47)30(50)39-16-24(45)40-19(5)28(48)44-27(18(3)4)33(53)54/h6-8,10-11,17-19,21-23,26-27H,9,12-16,35H2,1-5H3,(H,39,50)(H,40,45)(H,41,51)(H,42,52)(H,43,49)(H,44,48)(H,46,47)(H,53,54)(H4,36,37,38)/t19-,21-,22-,23-,26-,27-/m0/s1 InChIKey: VTLRXDHIWHEVPA-MLNOCLFBSA-N

Number_of_Residues

7