TPDB

3D PDB MODEL

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TPDB ID TPDB66297

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

PDWFLLL

FASTA

>TPDB66297|ACE inhibitors|length=7
PDWFLLL

Formula C47H66N8O10

Absent Amino Acids ARNCEQGHIKMSTYV

Common Amino Acids L

Mass 903.09

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -1

Boman Index -2.98

Hydrophobicity 1.171

Aliphatic Index 167.14

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 5500

Absorbance 280nm 609.02

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

3

L

0

K

0

M

1

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

7

Formula

C47H66N8O10

Mass

903.09

PI

3.10

Net Charge

-1

Boman Index

-2.98

Hydrophobicity

1.171

Chemical_Mass

903.0719

Monoisotopic_Mass

902.4886

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1.76 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors

Montone, C. M., Zenezini Chiozzi, R., Marchetti, N., Cerrato, A., Antonelli, M., Capriotti, A. L., Cavaliere C., Piovesana S.,Laganà A.

Title

Peptidomic Approach for the Identification of Peptides with Potential Antioxidant and Anti-Hyperthensive Effects Derived From Asparagus By-Products. Molecules, 24(19), 3627, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@H](CCC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=C[N]([H])C3=CC=CC=C23)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C47H66N8O10/c1-26(2)19-34(42(59)50-35(20-27(3)4)43(60)55-39(47(64)65)21-28(5)6)51-44(61)36(22-29-13-8-7-9-14-29)52-45(62)37(23-30-25-49-32-16-11-10-15-31(30)32)53-46(63)38(24-40(56)57)54-41(58)33-17-12-18-48-33/h7-11,13-16,25-28,33-39,48-49H,12,17-24H2,1-6H3,(H,50,59)(H,51,61)(H,52,62)(H,53,63)(H,54,58)(H,55,60)(H,56,57)(H,64,65)/t33-,34-,35-,36-,37-,38-,39-/m0/s1 InChIKey: BFZLRXSIXBSARL-ZTYVOHGWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

7