TPDB

3D PDB MODEL

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TPDB ID TPDB66296

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

MILLLFR

FASTA

>TPDB66296|ACE inhibitors|length=7
MILLLFR

Formula C44H76N10O8S1

Absent Amino Acids ANDCEQGHKPSTWYV

Common Amino Acids L

Mass 905.21

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +1

Boman Index -2.54

Hydrophobicity 2.300

Aliphatic Index 222.86

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

3

L

0

K

1

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C44H76N10O8S1

Mass

905.21

PI

11.05

Net Charge

+1

Boman Index

-2.54

Hydrophobicity

2.300

Chemical_Mass

905.1995

Monoisotopic_Mass

904.5551

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.12 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Toopcham T., Roytrakul S., Yongsawatdigul J.

Title

Characterization and identification of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from tilapia using Virgibacillus halodenitrificans SK1-3-7 proteinases. J. Funct. Foods, 14, 435-444, 2015

Year 2015

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCSC)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O InChI=1S/C44H76N10O8S/c1-10-28(8)36(54-37(55)30(45)18-20-63-9)42(60)53-34(23-27(6)7)40(58)51-32(21-25(2)3)38(56)50-33(22-26(4)5)39(57)52-35(24-29-15-12-11-13-16-29)41(59)49-31(43(61)62)17-14-19-48-44(46)47/h11-13,15-16,25-28,30-36H,10,14,17-24,45H2,1-9H3,(H,49,59)(H,50,56)(H,51,58)(H,52,57)(H,53,60)(H,54,55)(H,61,62)(H4,46,47,48)/t28-,30-,31-,32-,33-,34-,35-,36-/m0/s1 InChIKey: RPNURIMEGVHDTL-XQASUVORSA-N

Number_of_Residues

7