TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB66292

Peptide_Name

ACE inhibitor Anti-inflammatory peptide

Activity

ACE inhibitors Anti-inflammatory

Activity_category_statistics

Cardiometabolic peptides Immunity and inflammation peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Anti-inflammatory) peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

KPVAAP

FASTA

>TPDB66292|ACE inhibitors;Anti-inflammatory|length=6
KPVAAP

Formula C27H47N7O7

Absent Amino Acids RNDCEQGHILMFSTWY

Common Amino Acids AP

Mass 581.71

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 1.62

Hydrophobicity 0.117

Aliphatic Index 81.67

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C27H47N7O7

Mass

581.71

PI

10.10

Net Charge

+1

Boman Index

1.62

Hydrophobicity

0.117

Chemical_Mass

581.7029

Monoisotopic_Mass

581.3526

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 12.37 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Escudero E., Mora L., Toldrá F.

Title

Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chemistry, 161, 305-311, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H47N7O7/c1-15(2)21(32-23(36)19-10-7-13-33(19)26(39)18(29)9-5-6-12-28)24(37)30-16(3)22(35)31-17(4)25(38)34-14-8-11-20(34)27(40)41/h15-21H,5-14,28-29H2,1-4H3,(H,30,37)(H,31,35)(H,32,36)(H,40,41)/t16-,17-,18-,19-,20-,21-/m0/s1 InChIKey= PQBJWVUEMPXTAW-PXQJOHHUSA-N

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Martínez-Sánchez S. M., Pérez-Sánchez H., Gabaldón J. A., Abellán-Alemán J., Montoro-García S.

Title

Multifunctional peptides from Spanish dry-cured pork ham: endothelial responses and molecular modeling studies. Int. J. Mol. Sci., 20, 4204, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides: SMILES: N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H47N7O7/c1-15(2)21(32-23(36)19-10-7-13-33(19)26(39)18(29)9-5-6-12-28)24(37)30-16(3)22(35)31-17(4)25(38)34-14-8-11-20(34)27(40)41/h15-21H,5-14,28-29H2,1-4H3,(H,30,37)(H,31,35)(H,32,36)(H,40,41)/t16-,17-,18-,19-,20-,21-/m0/s1 InChIKey=PQBJWVUEMPXTAW-PXQJOHHUSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9955) the EROP-Moscow database

Number_of_Residues

7 6