TPDB

3D PDB MODEL

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TPDB ID TPDB66290

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

KEDVPSE

FASTA

>TPDB66290|ACE inhibitors|length=7
KEDVPSE

Formula C33H54N8O15

Absent Amino Acids ARNCQGHILMFTWY

Common Amino Acids E

Mass 802.84

PI 3.83

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 1

Net Charge -2

Boman Index 6.91

Hydrophobicity -1.800

Aliphatic Index 41.43

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

1

D

0

C

2

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

1

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 2 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

7

Formula

C33H54N8O15

Mass

802.84

PI

3.83

Net Charge

-2

Boman Index

6.91

Hydrophobicity

-1.800

Chemical_Mass

802.8243

Monoisotopic_Mass

802.3695

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Villegas J. M., Picariello G., Mamone G., Espeche Turbay M. B., Savoy de Giori G., Hebert E. M.

Title

Milk-derived angiotensin-I-converting enzyme-inhibitory peptides generated by Lactobacillus delbrueckii subsp. lactis CRL 581. Peptidomics 1: 22–29, 2014.

Year 2014

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(C(C)C)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(O)=O)C(O)=O InChI=1S/C33H54N8O15/c1-16(2)26(32(54)41-13-5-7-22(41)31(53)39-21(15-42)30(52)37-19(33(55)56)9-11-24(45)46)40-29(51)20(14-25(47)48)38-28(50)18(8-10-23(43)44)36-27(49)17(35)6-3-4-12-34/h16-22,26,42H,3-15,34-35H2,1-2H3,(H,36,49)(H,37,52)(H,38,50)(H,39,53)(H,40,51)(H,43,44)(H,45,46)(H,47,48)(H,55,56)/t17-,18-,19-,20-,21-,22-,26-/m0/s1 InChIKey: HSQZJAMECLIEOW-FFTHMYJOSA-N

Number_of_Residues

7