TPDB

3D PDB MODEL

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TPDB ID TPDB66286

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

EVSQGRP

FASTA

>TPDB66286|ACE inhibitors|length=7
EVSQGRP

Formula C31H53N11O12

Absent Amino Acids ANDCHILKMFTWY

Common Amino Acids REQGPSV

Mass 771.83

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 4.07

Hydrophobicity -1.443

Aliphatic Index 41.43

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

1

E

1

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

7

Formula

C31H53N11O12

Mass

771.83

PI

6.97

Net Charge

-0

Boman Index

4.07

Hydrophobicity

-1.443

Chemical_Mass

771.8169

Monoisotopic_Mass

771.3863

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 50.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Forghani B., Zarei M., Ebrahimpour A., Philip R., Bakar J., Hamid A. A., Saari N.

Title

Purification and characterization of angiotensin converting enzyme-inhibitory peptides derived from Stichopus horrens: Stability study against the ACE and inhibition kinetics. J. Funct. Foods, 20, 276-290, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C31H53N11O12/c1-15(2)24(41-25(48)16(32)7-10-23(46)47)28(51)40-19(14-43)27(50)39-17(8-9-21(33)44)26(49)37-13-22(45)38-18(5-3-11-36-31(34)35)29(52)42-12-4-6-20(42)30(53)54/h15-20,24,43H,3-14,32H2,1-2H3,(H2,33,44)(H,37,49)(H,38,45)(H,39,50)(H,40,51)(H,41,48)(H,46,47)(H,53,54)(H4,34,35,36)/t16-,17-,18-,19-,20-,24-/m0/s1 InChIKey: GGNJPCBEJCLZLS-KCKIOEHISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

7