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Peptide record

TPDB66282

ACE inhibitor ACE inhibitors standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66282
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
VYLPRM
Physicochemical Analysis
C36H59N9O8S1
ANDCEQGHIKFSTW
RLMPYV
777.98
9.88
1
0
4
+1
-0.40
0.417
113.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
191.52
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C36H59N9O8S1
777.98
9.88
+1
-0.40
0.417
777.9729
777.4194
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
2.32 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)O InChI=1S/C36H59N9O8S/c1-20(2)18-27(44-31(48)26(43-33(50)29(37)21(3)4)19-22-10-12-23(46)13-11-22)34(51)45-16-7-9-28(45)32(49)41-24(8-6-15-40-36(38)39)30(47)42-25(35(52)53)14-17-54-5/h10-13,20-21,24-29,46H,6-9,14-19,37H2,1-5H3,(H,41,49)(H,42,47)(H,43,50)(H,44,48)(H,52,53)(H4,38,39,40)/t24-,25-,26-,27-,28-,29-/m0/s1 InChIKey=DAVVKIOJPAJTFU-AQRCPPRCSA-N
Additional Detail Fields 1 fields
6