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Peptide record

TPDB66280

ACE inhibitor ACE inhibitors standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66280
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
VQKATY
Physicochemical Analysis
C32H52N8O10
RNDCEGHILMFPSW
AQKTYV
708.81
9.74
1
0
3
+1
0.67
-0.567
65.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1490
210.21
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
6
C32H52N8O10
708.81
9.74
+1
0.67
-0.567
708.8008
708.3794
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1.44 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C32H52N8O10/c1-16(2)25(35)30(47)38-22(12-13-24(34)43)29(46)37-21(7-5-6-14-33)28(45)36-17(3)27(44)40-26(18(4)41)31(48)39-23(32(49)50)15-19-8-10-20(42)11-9-19/h8-11,16-18,21-23,25-26,41-42H,5-7,12-15,33,35H2,1-4H3,(H2,34,43)(H,36,45)(H,37,46)(H,38,47)(H,39,48)(H,40,44)(H,49,50)/t17-,18+,21-,22-,23-,25-,26-/m0/s1 InChIKey=UTORUHOMEGGVHC-KSDVDEECSA-N
Additional Detail Fields 1 fields
6