TPDB

3D PDB MODEL

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TPDB ID TPDB66278

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

TNLDWY

FASTA

>TPDB66278|ACE inhibitors|length=6
TNLDWY

Formula C38H50N8O12

Absent Amino Acids ARCEQGHIKMFPSV

Common Amino Acids NDLTWY

Mass 810.86

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index -1.56

Hydrophobicity -1.017

Aliphatic Index 65.00

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 862.05

Polar Residues 3

number

0

A

0

R

1

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

1

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 0

Length

6

Formula

C38H50N8O12

Mass

810.86

PI

3.10

Net Charge

-1

Boman Index

-1.56

Hydrophobicity

-1.017

Chemical_Mass

810.8480

Monoisotopic_Mass

810.3536

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 1932.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Ma F.-F., Wang H., Wei C.-K., Thakur K., Wei Z.-J., Jiang L.

Title

Three Novel ACE Inhibitory Peptides Isolated From Ginkgo biloba Seeds: Purification, Inhibitory Kinetic and Mechanism. Front. Pharmacol., 9, 1579, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)O InChI=1S/C38H50N8O12/c1-18(2)12-25(42-35(54)27(15-30(39)49)45-37(56)32(40)19(3)47)33(52)44-28(16-31(50)51)36(55)43-26(14-21-17-41-24-7-5-4-6-23(21)24)34(53)46-29(38(57)58)13-20-8-10-22(48)11-9-20/h4-11,17-19,25-29,32,41,47-48H,12-16,40H2,1-3H3,(H2,39,49)(H,42,54)(H,43,55)(H,44,52)(H,45,56)(H,46,53)(H,50,51)(H,57,58)/t19-,25+,26+,27+,28+,29+,32+/m1/s1 InChIKey: AJTHYHIOJSLKOJ-CRUMNSIKSA-N

Number_of_Residues

6