TPDB

3D PDB MODEL

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TPDB ID TPDB66277

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

TGAPCR

FASTA

>TPDB66277|ACE inhibitors|length=6
TGAPCR

Formula C23H41N9O8S1

Absent Amino Acids NDEQHILKMFSWYV

Common Amino Acids ARCGPT

Mass 603.69

PI 9.01

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index 1.00

Hydrophobicity -0.483

Aliphatic Index 16.67

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

1

A

1

R

0

N

0

D

1

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

6

Formula

C23H41N9O8S1

Mass

603.69

PI

9.01

Net Charge

+1

Boman Index

1.00

Hydrophobicity

-0.483

Chemical_Mass

603.6916

Monoisotopic_Mass

603.2790

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 23.94 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Deng Z., Liu Y., Wang J., Wu S., Geng L., Sui Z., Zhang Q.

Title

Antihypertensive effects of two novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Gracilariopsis lemaneiformis (Rhodophyta) in spontaneously hypertensive rats (SHRs). Mar. Drugs, 16, Article No 299, 2018

Year 2018

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CS)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C23H41N9O8S/c1-11(29-16(34)9-28-20(37)17(24)12(2)33)21(38)32-8-4-6-15(32)19(36)31-14(10-41)18(35)30-13(22(39)40)5-3-7-27-23(25)26/h11-15,17,33,41H,3-10,24H2,1-2H3,(H,28,37)(H,29,34)(H,30,35)(H,31,36)(H,39,40)(H4,25,26,27)/t11-,12+,13-,14-,15-,17-/m0/s1 InChIKey: VEVGFNGDPJDSTM-ODIPTECFSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 The peptide causes decrease of blood pressure in spontaneously hypertensive rats.

Number_of_Residues

6