TPDB

3D PDB MODEL

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TPDB ID TPDB66276

Peptide_Name

ACE inhibitor from cuttlefish (Sepia officinalis)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

STHGVY

FASTA

>TPDB66276|ACE inhibitors|length=6
STHGVY

Formula C29H42N8O10

Absent Amino Acids ARNDCEQILKMFPW

Common Amino Acids GHSTYV

Mass 662.70

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 0.37

Hydrophobicity -0.367

Aliphatic Index 48.33

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 224.84

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

1

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 1

Length

6

Formula

C29H42N8O10

Mass

662.70

PI

7.77

Net Charge

+0

Boman Index

0.37

Hydrophobicity

-0.367

Chemical_Mass

662.6897

Monoisotopic_Mass

662.3014

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 19.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.

Title

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525

Year 2015

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CO)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C29H42N8O10/c1-14(2)23(27(44)35-21(29(46)47)8-16-4-6-18(40)7-5-16)36-22(41)11-32-26(43)20(9-17-10-31-13-33-17)34-28(45)24(15(3)39)37-25(42)19(30)12-38/h4-7,10,13-15,19-21,23-24,38-40H,8-9,11-12,30H2,1-3H3,(H,31,33)(H,32,43)(H,34,45)(H,35,44)(H,36,41)(H,37,42)(H,46,47)/t15-,19+,20+,21+,23+,24+/m1/s1 InChIKey=VLLDORWGGVRVNR-NRWKVABUSA-N

Number_of_Residues

6