TPDB

3D PDB MODEL

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TPDB ID TPDB66274

Peptide_Name

ACE inhibitor from cuttlefish (Sepia officinalis)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

RSIKGF

FASTA

>TPDB66274|ACE inhibitors|length=6
RSIKGF

Formula C32H54N10O8

Absent Amino Acids ANDCEQHLMPTWYV

Common Amino Acids RGIKFS

Mass 706.84

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +2

Boman Index 0.50

Hydrophobicity -0.383

Aliphatic Index 65.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

1

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C32H54N10O8

Mass

706.84

PI

11.49

Net Charge

+2

Boman Index

0.50

Hydrophobicity

-0.383

Chemical_Mass

706.8312

Monoisotopic_Mass

706.4114

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 32.74 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.

Title

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525

Year 2015

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCCCN)C(=O)NCC(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C32H54N10O8/c1-3-19(2)26(42-29(47)24(18-43)41-27(45)21(34)12-9-15-37-32(35)36)30(48)40-22(13-7-8-14-33)28(46)38-17-25(44)39-23(31(49)50)16-20-10-5-4-6-11-20/h4-6,10-11,19,21-24,26,43H,3,7-9,12-18,33-34H2,1-2H3,(H,38,46)(H,39,44)(H,40,48)(H,41,45)(H,42,47)(H,49,50)(H4,35,36,37)/t19-,21-,22-,23-,24-,26-/m0/s1 InChIKey=NAADMAYAQXLGQC-PSEZLDIXSA-N

Number_of_Residues

6