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Peptide record

TPDB66266

ACE inhibitor ACE inhibitors standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66266
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
LGHWVY
Physicochemical Analysis
C39H51N9O8
ARNDCEQIKMFPST
GHLWYV
773.89
7.77
1
0
4
+0
-2.31
0.367
113.33
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
6990
903.23
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
6
C39H51N9O8
773.89
7.77
+0
-2.31
0.367
773.8757
773.3849
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
6.25 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=C[N]([H])C3=CC=CC=C23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI=1S/C39H51N9O8/c1-21(2)13-28(40)35(51)43-19-33(50)45-31(16-25-18-41-20-44-25)36(52)46-30(15-24-17-42-29-8-6-5-7-27(24)29)37(53)48-34(22(3)4)38(54)47-32(39(55)56)14-23-9-11-26(49)12-10-23/h5-12,17-18,20-22,28,30-32,34,42,49H,13-16,19,40H2,1-4H3,(H,41,44)(H,43,51)(H,45,50)(H,46,52)(H,47,54)(H,48,53)(H,55,56)/t28-,30-,31-,32-,34-/m0/s1 InChIKey=ZDARFIAXPFJMAU-HAMFGRCQSA-N
Additional Detail Fields 1 fields
6