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Peptide record

TPDB66264

ACE inhibitor ACE inhibitors standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66264
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
LFLIKH
Physicochemical Analysis
C39H63N9O7
ARNDCEQGMPSTWYV
L
769.99
10.10
2
0
4
+1
-0.61
1.300
195.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
2
L
1
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C39H63N9O7
769.99
10.10
+1
-0.61
1.300
769.9711
769.4836
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.47 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)O InChI=1S/C39H63N9O7/c1-7-25(6)33(38(53)44-29(15-11-12-16-40)35(50)47-32(39(54)55)20-27-21-42-22-43-27)48-37(52)30(18-24(4)5)46-36(51)31(19-26-13-9-8-10-14-26)45-34(49)28(41)17-23(2)3/h8-10,13-14,21-25,28-33H,7,11-12,15-20,40-41H2,1-6H3,(H,42,43)(H,44,53)(H,45,49)(H,46,51)(H,47,50)(H,48,52)(H,54,55)/t25-,28-,29-,30-,31-,32-,33-/m0/s1 InChIKey=QGLPOCNPSKFDCC-GCNYMACQSA-N
Additional Detail Fields 1 fields
6