TPDB

3D PDB MODEL

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TPDB ID TPDB66262

Peptide_Name

ACE inhibitor from cuttlefish (Sepia officinalis)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

KNGDGY

FASTA

>TPDB66262|ACE inhibitors|length=6
KNGDGY

Formula C27H40N8O11

Absent Amino Acids ARCEQHILMFPSTWV

Common Amino Acids G

Mass 652.66

PI 6.68

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 1.72

Hydrophobicity -2.167

Aliphatic Index 0.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 228.30

Polar Residues 2

number

0

A

0

R

1

N

1

D

0

C

0

E

0

Q

2

G

0

H

0

I

0

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

6

Formula

C27H40N8O11

Mass

652.66

PI

6.68

Net Charge

-0

Boman Index

1.72

Hydrophobicity

-2.167

Chemical_Mass

652.6519

Monoisotopic_Mass

652.2807

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 51.63 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Balti R., Bougatef A., Sila A., Guillochon D., Dhulster P., Nedjar-Arroume N.

Title

Nine novel angiotensin I-converting enzyme (ACE) inhibitory peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates and antihypertensive effect of the potent active peptide in spontaneously hypertensive rats. Food Chem., 170, 519-525

Year 2015

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)N)C(=O)NCC(=O)N[C@@]([H])(CC(=O)O)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C27H40N8O11/c28-8-2-1-3-16(29)24(42)35-17(10-20(30)37)25(43)31-12-21(38)33-18(11-23(40)41)26(44)32-13-22(39)34-19(27(45)46)9-14-4-6-15(36)7-5-14/h4-7,16-19,36H,1-3,8-13,28-29H2,(H2,30,37)(H,31,43)(H,32,44)(H,33,38)(H,34,39)(H,35,42)(H,40,41)(H,45,46)/t16-,17-,18-,19-/m0/s1 InChIKey=KUYGHLBJQIXGRH-VJANTYMQSA-N

Number_of_Residues

6