TPDB

3D PDB MODEL

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TPDB ID TPDB66255

Peptide_Name

ACE inhibitor from thornback ray muscle (Raja clavata)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

ESAGIH

FASTA

>TPDB66255|ACE inhibitors|length=6
ESAGIH

Formula C25H40N8O10

Absent Amino Acids RNDCQLKMFPTWYV

Common Amino Acids AEGHIS

Mass 612.64

PI 5.13

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 2.64

Hydrophobicity -0.267

Aliphatic Index 81.67

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

0

D

0

C

1

E

0

Q

1

G

1

H

1

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C25H40N8O10

Mass

612.64

PI

5.13

Net Charge

-1

Boman Index

2.64

Hydrophobicity

-0.267

Chemical_Mass

612.6311

Monoisotopic_Mass

612.2858

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 371.60 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lassoued I., Mora L., Barkia, Aristoy M.-C., Nasri M., Toldra F.

Title

Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC1=CN=C[N]1[H])C(=O)O InChI=1S/C25H40N8O10/c1-4-12(2)20(24(41)31-16(25(42)43)7-14-8-27-11-29-14)33-18(35)9-28-21(38)13(3)30-23(40)17(10-34)32-22(39)15(26)5-6-19(36)37/h8,11-13,15-17,20,34H,4-7,9-10,26H2,1-3H3,(H,27,29)(H,28,38)(H,30,40)(H,31,41)(H,32,39)(H,33,35)(H,36,37)(H,42,43)/t12-,13-,15-,16-,17-,20-/m0/s1 InChIKey=NFBYCMWYFUISGO-GZKRCTFISA-N Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 371.60 uM.

Number_of_Residues

6