TPDB

3D PDB MODEL

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TPDB ID TPDB66250

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

YGNPVGGVGH

FASTA

>TPDB66250|ACE inhibitors|length=10
YGNPVGGVGH

Formula C42H61N13O13

Absent Amino Acids ARDCEQILKMFSTW

Common Amino Acids G

Mass 956.03

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index 1.07

Hydrophobicity -0.280

Aliphatic Index 58.00

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 155.85

Polar Residues 2

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

4

G

1

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 2

Length

10

Formula

C42H61N13O13

Mass

956.03

PI

7.77

Net Charge

+0

Boman Index

1.07

Hydrophobicity

-0.280

Chemical_Mass

956.0106

Monoisotopic_Mass

955.4498

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 522.04 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Złotek U., Jakubczyk A., Rybczyńska-Tkaczyk K., Ćwiek P., Baraniak B., Lewicki S.

Title

Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)O InChI=1S/C42H61N13O13/c1-21(2)35(39(64)49-19-33(60)52-28(42(67)68)13-24-15-45-20-50-24)53-34(61)17-46-31(58)16-48-40(65)36(22(3)4)54-38(63)29-6-5-11-55(29)41(66)27(14-30(44)57)51-32(59)18-47-37(62)26(43)12-23-7-9-25(56)10-8-23/h7-10,15,20-22,26-29,35-36,56H,5-6,11-14,16-19,43H2,1-4H3,(H2,44,57)(H,45,50)(H,46,58)(H,47,62)(H,48,65)(H,49,64)(H,51,59)(H,52,60)(H,53,61)(H,54,63)(H,67,68)/t26-,27-,28-,29-,35-,36-/m0/s1 InChIKey=WAZZXTNHTHAEGR-QVNLIAGCSA-N Inhibitor of Alpha-amylase (EC 3.2.1.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9777) Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9778) Inhibitor of lipoxygenase (LOX) according to the BIOPEP-UWM database of bioactive peptides (ID 9779) Inhibitor of cyclooxygenase-1 (COX-1) (EC 1.14.99.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9780) Inhibitor of cyclooxygenase-2 (COX-2) (EC 1.14.99.1) according to the BIOPEP-UWM database of bioactive peptides (ID 9781)

Number_of_Residues

10