TPDB

3D PDB MODEL

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TPDB ID TPDB66249

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

VSRHFASYAN

FASTA

>TPDB66249|ACE inhibitors|length=10
VSRHFASYAN

Formula C51H74N16O15

Absent Amino Acids DCEQGILKMPTW

Common Amino Acids AS

Mass 1151.25

PI 9.88

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index 0.11

Hydrophobicity -0.350

Aliphatic Index 49.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 129.42

Polar Residues 4

number

2

A

1

R

1

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

1

F

0

P

2

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1

Length

10

Formula

C51H74N16O15

Mass

1151.25

PI

9.88

Net Charge

+1

Boman Index

0.11

Hydrophobicity

-0.350

Chemical_Mass

1151.2285

Monoisotopic_Mass

1150.5503

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 210.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Forghani B., Zarei M., Ebrahimpour A., Philip R., Bakar J., Hamid A. A., Saari N.

Title

Purification and characterization of angiotensin converting enzyme-inhibitory peptides derived from Stichopus horrens: Stability study against the ACE and inhibition kinetics. J. Funct. Foods, 20, 276-290, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)O InChI=1S/C51H74N16O15/c1-25(2)40(53)49(80)67-38(23-69)47(78)61-32(11-8-16-57-51(54)55)43(74)64-35(19-30-21-56-24-58-30)46(77)62-33(17-28-9-6-5-7-10-28)44(75)60-27(4)42(73)66-37(22-68)48(79)63-34(18-29-12-14-31(70)15-13-29)45(76)59-26(3)41(72)65-36(50(81)82)20-39(52)71/h5-7,9-10,12-15,21,24-27,32-38,40,68-70H,8,11,16-20,22-23,53H2,1-4H3,(H2,52,71)(H,56,58)(H,59,76)(H,60,75)(H,61,78)(H,62,77)(H,63,79)(H,64,74)(H,65,72)(H,66,73)(H,67,80)(H,81,82)(H4,54,55,57)/t26-,27-,32-,33-,34-,35-,36-,37-,38-,40-/m0/s1 InChIKey: KBLVKBAJKISXOP-QLWJBNTCSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

10