TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB66248

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural ace inhibitors peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

SIQSQPQAFP

FASTA

>TPDB66248|ACE inhibitors|length=10
SIQSQPQAFP

Formula C49H75N13O16

Absent Amino Acids RNDCEGHLKMTWYV

Common Amino Acids Q

Mass 1102.21

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index 1.29

Hydrophobicity -0.620

Aliphatic Index 49.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

1

A

0

R

0

N

0

D

0

C

0

E

3

Q

0

G

0

H

1

I

0

L

0

K

0

M

1

F

2

P

2

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C49H75N13O16

Mass

1102.21

PI

6.02

Net Charge

-0

Boman Index

1.29

Hydrophobicity

-0.620

Chemical_Mass

1102.1943

Monoisotopic_Mass

1101.5437

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 560.00 µM

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Kohmura M., Nio N., Ariyoshi Y.

Title

Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of various beta-caseins. Agric.Biol.Chem. 54(4),1101-1102(1990)

Year 1990

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CO)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O)[C@@]([H])(C)CC InChI=1S/C49H75N13O16/c1-4-25(2)39(60-41(69)28(50)23-63)46(74)56-30(15-18-37(52)66)43(71)59-33(24-64)44(72)57-31(16-19-38(53)67)47(75)61-20-8-12-34(61)45(73)55-29(14-17-36(51)65)42(70)54-26(3)40(68)58-32(22-27-10-6-5-7-11-27)48(76)62-21-9-13-35(62)49(77)78/h5-7,10-11,25-26,28-35,39,63-64H,4,8-9,12-24,50H2,1-3H3,(H2,51,65)(H2,52,66)(H2,53,67)(H,54,70)(H,55,73)(H,56,74)(H,57,72)(H,58,68)(H,59,71)(H,60,69)(H,77,78)/t25-,26-,28-,29-,30-,31-,32-,33-,34-,35-,39-/m0/s1 InChIKey=HYPUMXOJIKZEID-SPYJFWNSSA-N

Number_of_Residues

10