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Peptide record

TPDB66188

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Bitter iDPPIV standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66188
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Bitter iDPPIV
Cardiometabolic peptides Food sensory peptides
FermFooDB Peptipedia Tastepeptides-Meta iDPPIV pep-lab
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Bitter, and iDPPIV) peptide sequence curated from FermFooDB, Peptipedia, Tastepeptides-Meta, and other sources, with an available 3D structural model.
Sequence
IPAVF
Physicochemical Analysis
C28H43N5O6
RNDCEQGHLKMSTWY
AIFPV
545.68
6.02
0
0
4
-0
-1.09
2.340
156.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C28H43N5O6
545.68
6.02
-0
-1.09
2.340
545.6692
545.3203
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Ahn J. E., Park S. Y., Atwal A., Gibbs B. F., Lee B. H.
Angiotensin I-converting enzyme (ACE) inhibitory peptides from whey fermented by Lactobacillus species. J. Food Biochem., 33, 587-602, 2009
2009
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H]([C@H](CC)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O InChI=1S/C28H43N5O6/c1-6-17(4)22(29)27(37)33-14-10-13-21(33)25(35)30-18(5)24(34)32-23(16(2)3)26(36)31-20(28(38)39)15-19-11-8-7-9-12-19/h7-9,11-12,16-18,20-23H,6,10,13-15,29H2,1-5H3,(H,30,35)(H,31,36)(H,32,34)(H,38,39)/t17-,18-,20-,21-,22-,23-/m0/s1 InChIKey=RDMIXXDHHVQQKJ-PPSMKJHDSA-N Antiviral peptide according to the BIOPEP-UWM database of bioactived peptides Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8620) the DFBP database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 502) the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
iDPPIV
44.70 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Silveira S. T., Martínez-Maqueda D., Recio I., Hernández-Ledesma B.
Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in beta-lactoglobulin. Food Chemistry 141, 1072-1077, 2013
2013
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H]([C@H](CC)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O InChI=1S/C28H43N5O6/c1-6-17(4)22(29)27(37)33-14-10-13-21(33)25(35)30-18(5)24(34)32-23(16(2)3)26(36)31-20(28(38)39)15-19-11-8-7-9-12-19/h7-9,11-12,16-18,20-23H,6,10,13-15,29H2,1-5H3,(H,30,35)(H,31,36)(H,32,34)(H,38,39)/t17-,18-,20-,21-,22-,23-/m0/s1 InChIKey=RDMIXXDHHVQQKJ-PPSMKJHDSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the MBPDB database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (D 502) the EROP-Moscow database
Additional Detail Fields 1 fields
5