TPDB

3D PDB MODEL

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TPDB ID TPDB66170

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from FermFooDB and Peptipedia, with an available 3D structural model.

Sequence

VAPFP

FASTA

>TPDB66170|ACE inhibitors|length=5
VAPFP

Formula C27H39N5O6

Absent Amino Acids RNDCEQGHILKMSTWY

Common Amino Acids P

Mass 529.64

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -0.33

Hydrophobicity 1.120

Aliphatic Index 78.00

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

2

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

5

Formula

C27H39N5O6

Mass

529.64

PI

6.02

Net Charge

-0

Boman Index

-0.33

Hydrophobicity

1.120

Chemical_Mass

529.6269

Monoisotopic_Mass

529.2891

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Wu N., Wuhanqimuge, Shuang Q.

Title

Screening, characterization, and mechanistic evaluation of Angiotensin converting enzyme inhibitory peptides derived from milk fermented with Lactobacillus delbrueckii QS306 with and without ultrahigh-pressure treatment. J. Agric. Food Chem., 45, 17420–17431, 2023

Year 2023

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H39N5O6/c1-16(2)22(28)24(34)29-17(3)25(35)31-13-7-11-20(31)23(33)30-19(15-18-9-5-4-6-10-18)26(36)32-14-8-12-21(32)27(37)38/h4-6,9-10,16-17,19-22H,7-8,11-15,28H2,1-3H3,(H,29,34)(H,30,33)(H,37,38)/t17-,19-,20-,21-,22-/m0/s1 InChIKey=XZRZOZBTIBSFHN-ZONLJJFTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5