TPDB

3D PDB MODEL

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TPDB ID TPDB66167

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural ace inhibitors peptide sequence curated from FermFooDB and Peptipedia, with an available 3D structural model.

Sequence

LRFF

FASTA

>TPDB66167|ACE inhibitors|length=4
LRFF

Formula C30H43N7O5

Absent Amino Acids ANDCEQGHIKMPSTWYV

Common Amino Acids F

Mass 581.72

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -2.01

Hydrophobicity 1.225

Aliphatic Index 97.50

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

2

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C30H43N7O5

Mass

581.72

PI

11.05

Net Charge

+1

Boman Index

-2.01

Hydrophobicity

1.225

Chemical_Mass

581.7046

Monoisotopic_Mass

581.3316

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 116.90 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Li Y., Sadiq F. A., Liu T. J., Chen J. C., He G. Q.

Title

Purification and identification of novel peptides with inhibitory effect against angiotensin I-converting enzyme and optimization of process conditions in milk fermented with the yeast Kluyveromyces marxianus. J. Funct. Foods. 2015, 16:278-288.

Year 2015

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccccc1)C(O)=O InChI=1S/C30H43N7O5/c1-19(2)16-22(31)26(38)35-23(14-9-15-34-30(32)33)27(39)36-24(17-20-10-5-3-6-11-20)28(40)37-25(29(41)42)18-21-12-7-4-8-13-21/h3-8,10-13,19,22-25H,9,14-18,31H2,1-2H3,(H,35,38)(H,36,39)(H,37,40)(H,41,42)(H4,32,33,34)/t22-,23-,24-,25-/m0/s1 InChIKey=AFMAIKCAEUPEPI-QORCZRPOSA-N

Number_of_Residues

4