TPDB

3D PDB MODEL

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TPDB ID TPDB66166

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

FermFooDB pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from FermFooDB, pep-lab, and Peptipedia, with an available 3D structural model.

Sequence

VLSRYP

FASTA

>TPDB66166|ACE inhibitors|length=6
VLSRYP

Formula C34H55N9O9

Absent Amino Acids ANDCEQGHIKMFTW

Common Amino Acids RLPSYV

Mass 733.87

PI 9.88

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index -0.04

Hydrophobicity -0.033

Aliphatic Index 113.33

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 203.03

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 1

Length

6

Formula

C34H55N9O9

Mass

733.87

PI

9.88

Net Charge

+1

Boman Index

-0.04

Hydrophobicity

-0.033

Chemical_Mass

733.8532

Monoisotopic_Mass

733.4110

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 36.70 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source FermFooDB

Authors Li Y., Sadiq F. A., Liu T. J., Chen J. C., He G. Q.

Title

Purification and identification of novel peptides with inhibitory effect against angiotensin I-converting enzyme and optimization of process conditions in milk fermented with the yeast Kluyveromyces marxianus. J. Funct. Foods., 2015, 16:278-288.

Year 2015

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C34H55N9O9/c1-18(2)15-23(40-31(49)27(35)19(3)4)29(47)42-25(17-44)30(48)39-22(7-5-13-38-34(36)37)28(46)41-24(16-20-9-11-21(45)12-10-20)32(50)43-14-6-8-26(43)33(51)52/h9-12,18-19,22-27,44-45H,5-8,13-17,35H2,1-4H3,(H,39,48)(H,40,49)(H,41,46)(H,42,47)(H,51,52)(H4,36,37,38)/t22-,23-,24-,25-,26-,27-/m0/s1 InChIKey: GWMMOCNECGMPES-QCOJBMJGSA-N

Number_of_Residues

6