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Peptide record

TPDB66073

YSA Tumor-homing Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB66073
YSA
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 13-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
Sequence
YSAYPDSVPMMSK
Physicochemical Analysis
C65H98N14O21S2
RNCEQGHILFTW
S
1475.69
6.63
1
1
6
-0
1.07
-0.446
30.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
201.94
5
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
2
M
0
F
2
P
3
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 2 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
13
C65H98N14O21S2
1475.69
6.63
-0
1.07
-0.446
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor neovasculature, Tumor cell
Homing
Breast cancer
EphA2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Dual targeting for metastatic breast cancer and tumor neovasculature by EphA2-mediated nanocarriers
2015
Guo Z et al. Int J Pharm. 2015 Sep 30 493(1-2):380-9.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
MDA-MB-231 Cell line, Endothelial cells (HUVEC)
doxorubicin (DOX), stealth liposomes (YSA-LP)
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer
EphA2

Source & Reference

TumorHoPe2.0
TumorHoPe2
YSA-conjugated mesoporous silica nanoparticles effectively target EphA2-overexpressing breast cancer cells
2018
Liu Z et al Cancer Chemother Pharmacol. 2018 Apr 81(4):687-695.

Other

MDA-MB-231, SKBR3, MCF7
Synthetic
Doxorubicin, mesoporous silica nanoparticles (MSNs) ,Annexin V-FITC
Additional Detail Fields 2 fields
doxorubicin (DOX), stealth liposomes (YSA-LP) Doxorubicin, mesoporous silica nanoparticles (MSNs) ,Annexin V-FITC
MDA-MB-231 Cell line, Endothelial cells (HUVEC) MDA-MB-231, SKBR3, MCF7