TPDB

3D PDB MODEL

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TPDB ID TPDB66068

Peptide_Name

GE11

Activity

Tumor-homing Peptides

Activity_category_statistics

Cancer-related peptides

Database_Source

TumorHoPe2.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.

Sequence

YHWYGYTPQNVI

FASTA

>TPDB66068|Tumor-homing Peptides|length=12
YHWYGYTPQNVI

Formula C75H97N17O19

Absent Amino Acids ARDCELKMFS

Common Amino Acids Y

Mass 1540.70

PI 7.67

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +0

Boman Index -2.35

Hydrophobicity -0.750

Aliphatic Index 56.67

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 9970

Absorbance 280nm 647.11

Polar Residues 6

number

0

A

0

R

1

N

0

D

0

C

0

E

1

Q

1

G

1

H

1

I

0

L

0

K

0

M

0

F

1

P

0

S

1

T

1

W

3

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 3 V: 1

Length

12

Formula

C75H97N17O19

Mass

1540.70

PI

7.67

Net Charge

+0

Boman Index

-2.35

Hydrophobicity

-0.750

Evidence 1 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Endothelial cell, Tumor cell, Tumor vessel

Homing or Targeting Targeting

Target Tumor Breast cancer, Colon cancer, Pancreatic ductal adenocarcinoma

Receptors Biomarker GFR

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Nano-enabled immunotherapy in cancer

Year 2022

Reference

US 11433143 B2

Patent US 11433143 B2

Other

Source Activity Label	Source Definition
Tumor-homing Peptides	TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.

InVitro ExVivo 4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell

InVivo Model BALB/c mice

Source Type Phage display library

Conjugate Payload PEGylated cholesterol , indoximod

Evidence 2 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Target Cell Tumor cell

Homing or Targeting Targeting

Target Tumor Breast cancer

Receptors Biomarker EGFR

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title Method of treating cancer

Year 2022

Reference

US 11298376 B2

Patent US 11298376 B2

Other

InVitro ExVivo Breast cancer cell line (MDA-MB-231, BT474)

InVivo Model female nude mice 5 weeks old

Source Type Synthetic

Conjugate Payload PEG moieties, LPEI

Evidence 3 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Year 2021

Reference

Madeline M Bashant et al. J Mol Model. 2021 Dec 28 28(1):16.

Evidence 4 Activity

Activity

Detail Source Activity Tumor-homing Peptides

Target

Homing or Targeting Targeting

Receptors Biomarker Epidermal growth factor receptor

Source & Reference

Database Source TumorHoPe2.0

Source TumorHoPe2

Title The use of tail-anchored protein chimeras to enhance liposomal cargo delivery

Year 2019

Reference

Abdelrehim A et al. PLoS One.2019 Feb 22 14(2):e0212701

Other

InVitro ExVivo HeLa M and BeWo

Source Type Synthetic

Conjugate Payload Cytochrome b5 (Cytb5)

Conjugate_Payload

PEGylated cholesterol , indoximod PEG moieties, LPEI Cytochrome b5 (Cytb5)

InVitro_ExVivo

4T1 breast cancer, CT26 colon cancer, pancreatic ductal adenocarcinoma (KPC) cell Breast cancer cell line (MDA-MB-231, BT474) HeLa M and BeWo

InVivo_Model

BALB/c mice female nude mice 5 weeks old