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Peptide record

TPDB66063

M2 Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB66063
M2
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
C-terminal: Amidated
Sequence
YEQDPWGVKWWY
Physicochemical Analysis
C83H101N17O20
ARNCHILMFST
W
1656.82
4.07
1
2
6
-1
-2.08
-1.458
24.17
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
19480
1175.75
3
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
1
E
1
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
3
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 3 Y: 2 V: 1
Chemical Descriptors
12
C83H101N17O20
1656.82
4.07
-1
-2.08
-1.458
Amidated
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Endometrial adenocarcinoma, Non-small cell Lung cancer (NSCLC)
TAMs (Tumor-associated macrophages), folate receptor alpha (FRα)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Utilizing glutathione-triggered nanoparticles to enhance chemotherapy of lung cancer by reprograming the tumor microenvironment
2018
Tao Cui et al. Int J Pharm. 2018 Dec 1 552(1-2):16-26

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
J774A.1 cells and A549 cells
male balb/c nude mice (20 ± 2 g),
Synthetic
Additional Detail Fields 2 fields
J774A.1 cells and A549 cells
male balb/c nude mice (20 ± 2 g),