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Peptide record

TPDB66062

Her-2-binding peptide Tumor-homing Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB66062
Her-2-binding peptide
Tumor-homing Peptides
Cancer-related peptides
TumorHoPe2.0
standard
No
A 12-aa standard natural tumor-homing peptides peptide sequence curated from TumorHoPe2.0, with an available 3D structural model.
N-terminal: fluorescein isothiocyanate (FITC)/ FPR675 near-infrared fluorescence (NIRF)
Sequence
YCDGFYACYMDV
Physicochemical Analysis
C65H84N12O20S3
RNEQHILKPSTW
Y
1449.63
2.92
0
2
7
-2
-2.29
0.367
32.50
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4595
316.98
5
Residue Composition
number
1
A
0
R
0
N
2
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
12
C65H84N12O20S3
1449.63
2.92
-2
-2.29
0.367
fluorescein isothiocyanate (FITC)/ FPR675 near-infrared fluorescence (NIRF)
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell
Homing
Bladder cancer
Her-2

Source & Reference

TumorHoPe2.0
TumorHoPe2
Bladder tumor-targeted delivery of pro-apoptotic peptide for cancer therapy
2016
Hyun-Kyung Jung et al. J Control Release. 2016 Aug 10:235:259-267.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
HT1376(human bladder tumor) cell line, BEAS-2B (normal bronchial epithelial cells), Jurkat (human T lymphocytes) cell line, HUVECs (human umbilical vein endothelial cells), JEG-3 and BeWo (human trophoblastic cells)
5-week-old BALB/c nu/nu male mice
Phage Display library
D-KLAKLAKKLAKLAK (KLA) peptide
Additional Detail Fields 3 fields
D-KLAKLAKKLAKLAK (KLA) peptide
HT1376(human bladder tumor) cell line, BEAS-2B (normal bronchial epithelial cells), Jurkat (human T lymphocytes) cell line, HUVECs (human umbilical vein endothelial cells), JEG-3 and BeWo (human trophoblastic cells)
5-week-old BALB/c nu/nu male mice